Maternal central obesity and birth size: a Mendelian randomization analysis
نویسندگان
چکیده
منابع مشابه
Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis
BACKGROUND Observational epidemiological studies indicate that maternal height is associated with gestational age at birth and fetal growth measures (i.e., shorter mothers deliver infants at earlier gestational ages with lower birth weight and birth length). Different mechanisms have been postulated to explain these associations. This study aimed to investigate the casual relationships behind t...
متن کاملObesity and Multiple Sclerosis: A Mendelian Randomization Study
BACKGROUND Observational studies have reported an association between obesity, as measured by elevated body mass index (BMI), in early adulthood and risk of multiple sclerosis (MS). However, bias potentially introduced by confounding and reverse causation may have influenced these findings. Therefore, we elected to perform Mendelian randomization (MR) analyses to evaluate whether genetically in...
متن کاملMendelian Randomization Causal Analysis Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations o...
متن کاملCausal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
CONTEXT Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. OBJECTIVES Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. DESIGN Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. SETTING Five cohorts from Denmark, Germany and Swe...
متن کاملGWAS-based Mendelian Randomization Path Analysis
GMRP can perform analyses of Mendelian randomization (MR),correlation, path of causal variables onto disease of interest and SNP annotation analysis. MR includes SNP selection with given criteria and regression analysis of causal variables on the disease to generate beta values of causal variables on the disease. Using the beta vectors, GMRP performs correlation and path analyses to construct p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Lipids in Health and Disease
سال: 2018
ISSN: 1476-511X
DOI: 10.1186/s12944-018-0831-4